Demo Chapter – Pharmacological Treatments, Continued Copy
Pharmacological Treatments, Continued (4, 5, 6)
- Agonists of the glutamate N-methyl-d-aspartate receptor.
- Indicated when other treatments fail or can’t be used.
- Amantadine or memantine are options if benzodiazepines or ECT were not effective.
- Dose, route, and frequency:
- Amantadine: 100mg daily titrated up to a max daily dose of 500mg given in 2-3 divided doses.
- Can be given in oral or parenteral formulation in same dose range.
- Memantine: daily dose of 10mg given orally.
- Length of therapy and response:
- Response to NMDA antagonists is generally seen within one day, with complete remission of symptoms within three weeks.
- The effects are slower with NMDA antagonists compared to lorazepam.