Demo Chapter – Pharmacological Treatments, Continued

Pharmacological Treatments, Continued (4, 5, 6)


  • Non-benzodiazepine agonist of GABA-A receptor in the brain.
  • Alternative to lorazepam.
  • Dose, route, and frequency:
    • 10 mg orally given once.
    • Max dose 40mg/day.
  • Length of therapy:
    • The dose is generally given once.
    • Administration can be repeated on a subsequent day.
  • Response Rate:
    • Symptom improvement occurs 15-30 minutes after administration and lasts 2-5 hours.
    • It produces a prompt response and a 50% reduction of symptoms.
(4) Bartolommei, N., Lattanzi, L., Callari, A., Cosentino, L., Luchini, F., & Mauri, M. (2012). Catatonia: a critical review and therapeutic recommendations. Journal of psychopathology, 18, p. 235.
(5) Moore, D. P. & Jefferson, J. W. (2004). Catatonia. In handbook of medical psychiatry, 2nd ed. St. Louis, mo: mosby, pp. 292-293.
(6) American psychiatric association practice guideline for the treatment of patients with schizophrenia, second edition, 2004 http://www.Psych.Org/mainmenu/psychiatricpractice/Practiceguidelines_1.Aspx